Journal article

Prediagnostic Physical Activity and Colorectal Cancer Survival: Overall and Stratified by Tumor Characteristics

Sheetal Hardikar, Polly A Newcomb, Peter T Campbell, Aung Ko Win, Noralane M Lindor, Daniel D Buchanan, Karen W Makar, Mark A Jenkins, John D Potter, Amanda I Phipps

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION | AMER ASSOC CANCER RESEARCH | Published : 2015

Abstract

BACKGROUND: Physical activity is associated with a lower incidence of colorectal cancer; however, the relationship of physical activity with colorectal cancer survival is not yet clear. We evaluated the association between prediagnostic physical activity and colorectal cancer survival, overall and accounting for tumor markers associated with colorectal cancer survival: BRAF and KRAS mutation status and microsatellite instability (MSI) status. METHODS: Participants were 20- to 74-year-old colorectal cancer patients diagnosed between 1998 and 2007 from the population-based Seattle Colon Cancer Family Registry (S-CCFR). Self-reported physical activity in the years preceding colorectal cancer di..

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Grants

Awarded by National Cancer Institute


Awarded by CCFR center: Seattle Colorectal Cancer Family Registry


Awarded by CCFR center: Australasian Colorectal Cancer Family Registry


Awarded by CCFR center: Mayo Clinic Cooperative Family Registry for Colon Cancer Studies


Awarded by CCFR center: Ontario Familial Colorectal Cancer Registry


Awarded by CCFR center: University of Hawaii Colorectal Cancer Family Registry


Awarded by CCFR center: USC Consortium Colorectal Cancer Family Registry


Awarded by NATIONAL CANCER INSTITUTE


Funding Acknowledgements

This work was supported by grant UM1CA167551 from the National Cancer Institute and through cooperative agreements with the following CCFR centers: Seattle Colorectal Cancer Family Registry (U01/U24 CA074794; to P.A. Newcomb and J.D. Potter), Australasian Colorectal Cancer Family Registry (U01 CA074778 and U01/U24 CA097735; to D.D. Buchanan, M.A. Jenkins), Mayo Clinic Cooperative Family Registry for Colon Cancer Studies (U01/U24 CA074800; to N.M. Lindor), Ontario Familial Colorectal Cancer Registry (U01/U24 CA074783), University of Hawaii Colorectal Cancer Family Registry (U01/U24 CA074806), USC Consortium Colorectal Cancer Family Registry (U01/U24 CA074799). In addition, National Cancer Institute grants R25CA094880 (to S. Hardikar), R03CA165153 (to K.W. Makar), K05CA152715 (to P.A. Newcomb), and K07CA172298 (A.I. Phipps) have also supported this work. Paraffin-embedded tumor tissue for the Seattle Colorectal Cancer Family Registry was provided by The Jeremy Jass Memorial Pathology Bank.