Journal article

Mendelian Randomization Study of Body Mass Index and Colorectal Cancer Risk

Aaron P Thrift, Jian Gong, Ulrike Peters, Jenny Chang-Claude, Anja Rudolph, Martha L Slattery, Andrew T Chan, Adame Locke, Bratati Kahali, Anne E Justice, Tune H Pers, Steven Gallinger, Richard B Hayes, John A Baron, Bette J Caan, Shuji Ogino, Sonja I Berndt, Stephen J Chanock, Graham Casey, Robert W Haile Show all

Cancer Epidemiology Biomarkers & Prevention | AMER ASSOC CANCER RESEARCH | Published : 2015

Grants

Awarded by Mayo Clinic Cooperative Family Registry for Colon Cancer Studies


Awarded by University of Hawaii Colorectal Cancer Family Registry


Awarded by Familial Colorectal Neoplasia Collaborative Group


Awarded by NIH


Awarded by National Cancer Institute, NIH, U.S. Department of Health and Human Services


Awarded by National Cancer Institute, NIH


Awarded by NIH: Australasian Colorectal Cancer Family Registry


Awarded by Ontario Registry for Studies of Familial Colorectal Cancer


Awarded by Seattle Colorectal Cancer Family Registry


Awarded by German Research Council (Deutsche Forschungsgemeinschaft)


Awarded by German Federal Ministry of Education and Research


Awarded by NHS by the NIH


Awarded by PHS by the NIH


Awarded by NIH, Genes, Environment and Health Initiative (GEI)


Awarded by NIH GEI


Awarded by National Heart, Lung, and Blood Institute, NIH, U.S. Department of Health and Human Services


Awarded by Lundbeck Foundation


Funding Acknowledgements

N.M. Lindor was supported through the Mayo Clinic Cooperative Family Registry for Colon Cancer Studies (U01/U24 CA074800). L. Le Marchand was supported through the University of Hawaii Colorectal Cancer Family Registry (U01/U24 CA074806). J.A. Baron was supported through the Familial Colorectal Neoplasia Collaborative Group (U01 CA074799). This work was supported by grants from the NIH (R01 CA151993 to S. Ogino; R01 CA137178 to A.T. Chan; P01 CA53996 and R01 AG14358 to L. Hsu). M. Song was supported by a grant from the NIH (1U54CA155626-01). M. Du was supported by a grant from the NIH (R25 CA094880). A.E. Locke was supported by a grant from the NIH (R01 DK062370).GECCO is supported by National Cancer Institute, NIH, U.S. Department of Health and Human Services (U01 CA137088; R01 CA059045).CCFR is supported by NIH (UM1 CA167551) and through cooperative agreements with members of the Colon Cancer Family Registry and PIs. This genome-wide scan was supported by the National Cancer Institute, NIH by U01 CA122839 and R01 CA143237 to Graham Casey. The content of this article does not necessarily reflect the views or policies of the National Cancer Institute or any of the collaborating centers in the Colon Cancer Family Registry (CCFR), nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. Government or the CCFR. The following CCFR centers contributed data to this article and were supported by NIH: Australasian Colorectal Cancer Family Registry (U01 CA074778 and U01/U24 CA097735), Ontario Registry for Studies of Familial Colorectal Cancer (U01/U24 CA074783), Seattle Colorectal Cancer Family Registry (U01/U24 CA074794).DACHS is supported by German Research Council (Deutsche Forschungsgemeinschaft, BR 1704/6-1, BR 1704/6-3, BR 1704/6-4 and CH 117/1-1), and the German Federal Ministry of Education and Research (01KH0404 and 01ER0814).DALS is supported by NIH (R01 CA48998 to M.L. Slattery).HPFS is supported by the NIH (P01 CA 055075, UM1 CA167552, R01 137178, R01 CA 151993, and P50 CA 127003), NHS by the NIH (R01 CA137178, P01 CA 087969, R01 CA151993, and P50 CA 127003), and PHS by the NIH (R01 CA042182).OFCCR is supported by NIH, through funding allocated to the Ontario Registry for Studies of Familial Colorectal Cancer (U01 CA074783); see CCFR section above. Additional funding toward genetic analyses of OFCCR includes the Ontario Research Fund, the Canadian Institutes of Health Research, and the Ontario Institute for Cancer Research, through generous support from the Ontario Ministry of Research and Innovation.PLCO is supported by the Intramural Research Program of the Division of Cancer Epidemiology and Genetics and supported by contracts from the Division of Cancer Prevention, National Cancer Institute, NIH, DHHS. In addition, a subset of control samples was genotyped as part of the Cancer Genetic Markers of Susceptibility (CGEMS) Prostate Cancer GWAS (Yeager, M. and colleagues. Genome-wide association study of prostate cancer identifies a second risk locus at 8q24. Nat Genet 2007 May;39(5):64-59), Colon CGEMS pancreatic cancer scan (PanScan) (Amundadottir, L. and colleagues. Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer. Nat Genet. 2009 Sep;41(9):986-90, and Petersen, G.M. and colleagues. A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33. Nat Genet. 2010 Mar;42(3):224-8), and the Lung Cancer and Smoking study (Landi M.T., and colleagues. A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinoma. Am J Hum Genet. 2009 Nov;85(5):679-91). The prostate and PanScan study datasets were accessed with appropriate approval through the dbGaP online resource (http://cgems.cancer.gov/data/) accession numbers phs000207. v1.p1 and phs000206.v3.p2, respectively, and the lung datasets were accessed from the dbGaP website (http://www.ncbi.nlm.nih.gov/gap) through accession number phs000093.v2.p2. Funding for the Lung Cancer and Smoking study was provided by NIH, Genes, Environment and Health Initiative (GEI) Z01 CP 010200, NIH U01 HG004446, and NIH GEI U01 HG 004438. For the lung study, the GENEVA Coordinating Center provided assistance with genotype cleaning and general study coordination, and the Johns Hopkins University Center for Inherited Disease Research conducted genotyping.PMH is supported by NIH (R01 CA076366 to P.A. Newcomb).VITAL is supported by NIH (K05 CA154337).The WHI program is funded by the National Heart, Lung, and Blood Institute, NIH, U.S. Department of Health and Human Services through contracts HHSN268201100046C, HHSN268201100001C, HHSN268201100002C, HHSN268201100003C, HHSN268201100004C, and HHSN271201100004C.