Journal article

Stimulus-dependent differences in signalling regulate epithelial-mesenchymal plasticity and change the effects of drugs in breast cancer cell lines

J Cursons, KJ Leuchowius, M Waltham, E Tomaskovic-Crook, M Foroutan, CP Bracken, A Redfern, EJ Crampin, I Street, MJ Davis, EW Thompson

Cell Communication and Signaling | BioMed Central | Published : 2015

Abstract

INTRODUCTION: The normal process of epithelial mesenchymal transition (EMT) is subverted by carcinoma cells to facilitate metastatic spread. Cancer cells rarely undergo a full conversion to the mesenchymal phenotype, and instead adopt positions along the epithelial-mesenchymal axis, a propensity we refer to as epithelial mesenchymal plasticity (EMP). EMP is associated with increased risk of metastasis in breast cancer and consequent poor prognosis. Drivers towards the mesenchymal state in malignant cells include growth factor stimulation or exposure to hypoxic conditions. METHODS: We have examined EMP in two cell line models of breast cancer: the PMC42 system (PMC42-ET and PMC42-LA sublines)..

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Grants

Awarded by National Breast Cancer Foundation - EMPathy Breast Cancer Network


Awarded by National Breast Cancer Foundation


Awarded by Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology


Funding Acknowledgements

This work was supported in part by National Breast Cancer Foundation funding of the EMPathy Breast Cancer Network (CG-10-04), a National Collaborative Research Program. EWT was supported in part by the National Breast Cancer Foundation (Australia) and Cancer Australia. MJD is funded by National Breast Cancer Foundation ECF-14-043. This research was in part conducted and funded by the Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology (project number CE140100036). This study benefited from support by the Victorian Government's Operational Infrastructure Support Program to St. Vincent's Institute and The Walter and Eliza Hall Institute.