Conference Proceedings

Investigation of determinants of atypical femoral fractures using Multiscale computational modeling

S Martelli, P Pivonka, PR Ebeling

IFMBE Proceedings | Published : 2014


Atypical femoral fractures (AFF) are predominantly transverse stress fractures from the lateral aspect of the subtrochanteric and diaphyseal region for which long-term bisphosphonate treatment have been suggested an important determinants. However, the physiological loading environment triggering AFFs in typical femoral regions remain largely unexplored. The aim of this study was to test the hypothesis that typical AFFs onset location is associated with high daily cyclic tensile strains. The study was based on body- and organlevel models from a single donor (female, 81- years- old) and motion data recorded from a body-matched volunteer (female, 25 years-old). Models were the donor’s lower-li..

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