Journal article

Endolymphatic hydrops is prevalent in the first weeks following cochlear implantation

H Smeds, HT Eastwood, AJ Hampson, P Sale, LJ Campbell, BD Arhatari, S Mansour, SJ O'Leary

HEARING RESEARCH | ELSEVIER SCIENCE BV | Published : 2015

Abstract

AIM: To explore morphological or electrophysiological evidence for the presence of endolymphatic hydrops (EH) in guinea pig cochleae in the first 3 months after cochlear implantation. METHODS: Dummy silastic electrodes were implanted atraumatically into the basal turn of scala tympani via a cochleostomy. Round window electrocochleography (ECochG) was undertaken prior to and after implantation. Animals survived for 1, 7, 28 or 72 days prior to a terminal experiment, when ECochG was repeated. The cochleae were imaged using micro-CT after post-fixing with osmium tetroxide to reveal the inner ear soft tissue structure. EH was assessed by visual inspection at a series of frequency specific places..

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Grants

Awarded by Australian National Health and Medical Research Council


Awarded by Action on Hearing Loss


Funding Acknowledgements

The authors would like to thank Action on Hearing Loss and the Australian National Health and Medical Research Council (Project Grant 1007948) for their financial support. To Helen Feng (who manufactured dummy electrodes), Michelle Stirling (who managed animal husbandry matters) and Sjaak Klis (who kindly provided gold ball recording electrodes): we thank you for your assistance.