Journal article
Prospective progression from high-prevalence disorders to bipolar disorder: Exploring characteristics of pre-illness stages
A Ratheesh, SM Cotton, JK Betts, A Chanen, B Nelson, CG Davey, PD McGorry, M Berk, A Bechdolf
Journal of Affective Disorders | Published : 2015
Abstract
Abstract Background Identification of risk factors within precursor syndromes, such as depression, anxiety or substance use disorders (SUD), might help to pinpoint high-risk stages where preventive interventions for Bipolar Disorder (BD) could be evaluated. Methods We examined baseline demographic, clinical, quality of life, and temperament measures along with risk clusters among 52 young people seeking help for depression, anxiety or SUDs without psychosis or BD. The risk clusters included Bipolar At-Risk (BAR) and the Bipolarity Index as measures of bipolarity and the Ultra-High Risk assessment for psychosis. The participants were followed up for 12 months to identify conversion to BD. Tho..
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Awarded by Brain and Behavior Research Foundation
Funding Acknowledgements
The primary study was funded by a NARSAD independent investigator to AB and by the German Research Foundation (Be 3697/1-1). The funding sources had no involvement in the study design, analysis, preparation of the manuscript and the decision to submit the manuscript.