Perforin and granzymes: function, dysfunction and human pathology
Ilia Voskoboinik, James C Whisstock, Joseph A Trapani
Nature Reviews Immunology | NATURE PUBLISHING GROUP | Published : 2015
I.V. and J.C.W. are supported by fellowships from the National Health and Medical Research Council of Australia (NHMRC). I.V., J.C.W. and J.A.T. are supported by project grants from the NHMRC. J.C.W. is supported by the Australian Research Council (ARC) and he acknowledges the support of an ARC Federation fellowship. J.A.T. is supported by a programme grant from the NHMRC. The authors thank the many members of their laboratories, especially J.A. Lopez and A.J. Brennan, and their collaborators, especially H. Saibil, M.A. Dunstone, R. H. P. Law and N. Lukoyanova, for their contributions to many of the findings discussed in this Review.