Toward Omics-Based, Systems Biomedicine, and Path and Drug Discovery Methodologies for Depression-Inflammation Research
Michael Maes, Gabriel Nowak, Javier R Caso, Juan Carlos Leza, Cai Song, Marta Kubera, Hans Klein, Piotr Galecki, Cristiano Noto, Enrico Glaab, Rudi Balling, Michael Berk
MOLECULAR NEUROBIOLOGY | SPRINGER | Published : 2016
Meta-analyses confirm that depression is accompanied by signs of inflammation including increased levels of acute phase proteins, e.g., C-reactive protein, and pro-inflammatory cytokines, e.g., interleukin-6. Supporting the translational significance of this, a meta-analysis showed that anti-inflammatory drugs may have antidepressant effects. Here, we argue that inflammation and depression research needs to get onto a new track. Firstly, the choice of inflammatory biomarkers in depression research was often too selective and did not consider the broader pathways. Secondly, although mild inflammatory responses are present in depression, other immune-related pathways cannot be disregarded as n..View full abstract
Awarded by NHMRC
MB is supported by a NHMRC Senior Principal Research Fellowship (GNT1059660).