Journal article

Measurement of cortical porosity of the proximal femur improves identification of women with nonvertebral fragility fractures

LA Ahmed, R Shigdel, RM Joakimsen, OP Eldevik, EF Eriksen, A Ghasem-Zadeh, Y Bala, R Zebaze, E Seeman, A Bjornerem



UNLABELLED: We tested whether cortical porosity of the proximal femur measured using StrAx1.0 software provides additional information to areal bone mineral density (aBMD) or Fracture Risk Assessment Tool (FRAX) in differentiating women with and without fracture. Porosity was associated with fracture independent of aBMD and FRAX and identified additional women with fractures than by osteoporosis or FRAX thresholds. INTRODUCTION: Neither aBMD nor the FRAX captures cortical porosity, a major determinant of bone strength. We therefore tested whether combining porosity with aBMD or FRAX improves identification of women with fractures. METHODS: We quantified femoral neck (FN) aBMD using dual-ener..

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Awarded by North Norwegian Health Authorities

Funding Acknowledgements

The North Norwegian Health Authorities funded the study (ID 5645 1002-11, ID 9167/SFP1090-13, ID 9168/SFP1135-13) but had no role in design and conduct of the study; in the collection, analyses, and interpretation of the data; or in the preparation, review, or approval of the manuscript. The Tromso Study provided access to data, staff at the Department of Research at the University Hospital of North Norway (UNN) recruited women, staff at the Department of Radiology and Department of Radiation, UNN scanned the patients, organized the radiation procedures and the CT images, and StraxCorp, Melbourne analyzed the CT images.