Journal article
Gametocyte clearance kinetics determined by quantitative magnetic fractionation in Melanesian children with uncomplicated malaria treated with artemisinin combination therapy
S Karl, M Laman, BR Moore, J Benjamin, T Koleala, C Ibam, B Kasian, PM Siba, A Waltmann, I Mueller, RC Woodward, TG St. Pierre, TME Davis
Antimicrobial Agents and Chemotherapy | AMER SOC MICROBIOLOGY | Published : 2015
DOI: 10.1128/AAC.00136-15
Abstract
Quantitative magnetic fractionation and a published mathematical model were used to characterize between-treatment differences in gametocyte density and prevalence in 70 Papua New Guinean children with uncomplicated Plasmodium falciparum and/or Plasmodium vivax malaria randomized to one of two artemisinin combination therapies (artemether-lumefantrine or artemisinin-naphthoquine) in an intervention trial. There was an initial rise in peripheral P. falciparum gametocyte density with both treatments, but it was more pronounced in the artemisinin-naphthoquine group. Model-derived estimates of the median pretreatment sequestered gametocyte population were 21/μl for artemether-lumefantrine and 61..
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Funding Acknowledgements
This study was funded by National Health and Medical Research Council (NHMRC) of Australia grant 634343. S.K. was supported by NHMRC early career fellowship 1052760, M.L. by an Australian award Ph.D. scholarship, B.R.M. by NHMRC early career fellowship 1036951, T.K. by an Esso-Highlands PNG Institute of Medical Research scholarship, R.C.W. by ARC discovery grant 120103560, I.M. by NHMRC senior research fellowship 1043345, and T.M.E.D. by NHMRC practitioner fellowship 572561.