Journal article

Kruppel-ling of IRF4-Dependent DCs into Two Functionally Distinct DC Subsets

Sammy Bedoui, William R Heath

IMMUNITY | CELL PRESS | Published : 2015

Abstract

IRF4-dependent DCs have been associated with induction of both Th1 and Th17 cells. In this issue of Immunity, Tussiwand et al. (2015) demonstrate that a dependence on KLF4 identifies a subset of IRF4-dependent DC that preferentially promotes Th2 cell differentiation.