Effects of third generation P-glycoprotein inhibitors on the sensitivity of drug-resistant and -susceptible isolates of Haemonchus contortus to anthelmintics in vitro
Ali Raza, Steven R Kopp, Abdul Jabbar, Andrew C Kotze
VETERINARY PARASITOLOGY | ELSEVIER SCIENCE BV | Published : 2015
P-glycoproteins (P-gps) play an important role in the sensitivity of nematodes to anthelmintic drugs. They have been implicated in a number of anthelmintic resistances, particularly for macrocyclic lactone drugs. Hence, inhibition of nematode P-gps has been suggested as a means of reversing some types of anthelmintic resistance. The present study aimed to investigate the ability of the most-recently developed group of P-gp inhibitors (the so-called 'third generation' of inhibitors) including tariquidar, zosuquidar and elacridar, to increase the sensitivity of Haemonchus contortus larvae to various anthelmintics (ivermectin, levamisole and thiabendazole) in vitro. We compared these compounds ..View full abstract
AR is supported by an International Postgraduate Research Scholarship from the Australian Government, and a University of Queensland Centennial Scholarship. The authors have no conflicts of interest concerning the work reported in this paper.