Journal article

The beta c receptor family - Structural insights and their functional implications

Sophie E Broughton, Tracy L Nero, Urmi Dhagat, Winnie L Kan, Timothy R Hercus, Denis Tvorogov, Angel F Lopez, Michael W Parker

Cytokine | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD | Published : 2015

Abstract

Granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-3 (IL-3) and IL-5 are members of a small family of cytokines that share a beta receptor subunit (βc). These cytokines regulate the growth, differentiation, migration and effector function activities of many hematopoietic cells in bone marrow, blood and sites of inflammation. Excessive or aberrant signaling can result in chronic inflammatory conditions and myeloid leukemias. The crystal structures of the GM-CSF ternary complex, the IL-5 binary complex and the very recent IL-3 receptor alpha subunit build upon decades of structure-function studies, giving new insights into cytokine-receptor specificity and signal transducti..

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Grants

Funding Acknowledgements

This work was supported by grants from the National Health and Medical Research Council of Australia (NHMRC) to T.R.H., M.W.P and A.F.L. and from the Australian Cancer Research Foundation to M.W.P. Funding from the Victorian Government Operational Infrastructure Support Scheme to St Vincent's Institute is acknowledged. S.E.B is a Postdoctoral Fellow supported by the Leukaemia Foundation. U.D. and M.W.P. are NHMRC Postdoctoral and Research Fellows, respectively.