Journal article
PROLONGED REGIONAL VASOCONSTRICTION PRODUCED BY N-G-NITRO-L-ARGININE IN CONSCIOUS SHEEP
JJ TRESHAM, EJ COOPER, JA BEDNARIK, GJ DUSTING, CN MAY
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY | LIPPINCOTT-RAVEN PUBL | Published : 1994
Abstract
Nitric oxide (NO) is a potent endothelium-derived vasodilator whose synthesis can be blocked both in vitro and in vivo by structural analogues of its precursor, L-arginine (L-ARG). We examined the dose-response profile of one such analogue, NG-nitro-L-arginine (NOLA) in conscious sheep (n = 4) and used continuous monitoring techniques to study long-term changes in mean arterial pressure (MAP), heart rate (HR), and cardiac output (CO) and the relative responsiveness of the coronary, mesenteric, renal, and hindlimb vascular beds to NOLA [10 mg/kg, intravenous (i.v.) bolus] in 5 sheep. NOLA (3 and 10 mg/kg) increased MAP at 1 h from 73 +/- 4 to 86 +/- 3 mm Hg (p < 0.05) and 73 +/- 1 to 106 +/- ..
View full abstract