Journal article

Evidence against a central pressor mechanism for adrenocortical steroid hypertension in sheep.

JJ Tresham, JP Coghlan, CN May

CLINICAL AND EXPERIMENTAL HYPERTENSION | TAYLOR & FRANCIS INC | Published : 1996

Abstract

The possibility that corticotropin (ACTH)-induced hypertension results from a direct central effect of the adrenocortical steroids released by ACTH was investigated in sheep. Using two approaches, steroid levels were increased in the brain while peripheral levels remained sub-pressor. The blood pressure response to intravenous infusion of a combination of 7 steroids (aldosterone, cortisol, deoxycorticosterone, corticosterone, 11-deoxycortisol, 17 alpha hydroxyprogesterone and 17 alpha 20 alpha dihydroxyprogesterone), which causes a similar pressor effect to ACTH, was compared with that caused by intracarotid infusion of the steroids at rates calculated to give concentrations in the brain equ..

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University of Melbourne Researchers