Effects of infusion of combinations of adrenocorticosteroids on systemic and regional haemodynamics in conscious sheep

Abstract

Objective. To compare the cardiovascular, metabolic and endocrine responses to infusions of two combinations of adrenocorticosteroids and to determine their contribution to the haemodynamic effects of corticotrophin. Methods. The effect of 5 day's infusion of combinations of seven corticosteroids (aldosterone, cortisol, corticosterone, 11-deoxycorticosterone, 11-deoxycortisol, 17α-hydroxyprogesterone and 17α-hydroxy-20α-dihydroprogesterone and five corticosteroids (17α-hydroxyprogesterone and 17α,20α-hydroxyprogesterone omitted) on arterial pressure, cardiac output (measured using electromagnetic flow probes) and regional blood flows (measured using transit-time flow probes) was determined i..