Journal article

Extensive overlap of mu-opioid and nicotinic sensitivity in cortical interneurons

Isabelle Ferezou, Elisa L Hill, Bruno Cauli, Nathalie Gibelin, Takeshi Kaneko, Jean Rossier, Bertrand Lambolez

Cerebral Cortex | OXFORD UNIV PRESS INC | Published : 2007


We studied mu-opioid transmission in acute slices of rat neocortex using whole-cell recordings and single-cell reverse transcription-polymerase chain reaction. The mu-opioid receptor (MOR) was found in gamma-aminobutyric acidergic (GABAergic) interneurons that were either layer I cells frequently expressing neuropeptide Y or layers II-V cells expressing vasoactive intestinal peptide and enkephalin (Enk). We found that mu-opioid agonists inhibit these interneurons that are selectively excited by nicotinic agonists. The extensive overlap of mu-opioid and nicotinic responsiveness allowed mu-opioid agonists to inhibit nicotinic excitation of responsive interneurons and of their GABAergic output ..

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University of Melbourne Researchers