Expression of complement 3 receptors (CR1 and CR3) on neutrophils and erythrocytes in patients with IgA nephropathy

Abstract

Expression of C3 receptors (CR1 and CR3) on neutrophils (PMN) was measured in 26 patients with IgA nephropatahy (IgA N), 17 normal persons, and 8 patients with non-IgA glomerulonephritis (non-IgA GN) by fluorescence activated cell sorting after labeling with monoclonal antibodies. Mean channel fluorescence for both CR1 and CR3 on PMN was significantly higher in IgA N patients than in either control group (p < 0.01), (CR1 mean ± SD 42.5 ± 10.4 in IgA N, 31.7 ± 11.5 in normal controls, 27.8 ± 9.0 in non-IgA GN; CR3 94.0 ± 16.5, 75.0 ± 16.6 and 76.7 ± 15.6, respectively). No differences were found between the two control groups or between IgA N patients with normal and impaired renal function. ..