Journal article

DEFECTIVE INVIVO FC-RECEPTOR AND C3B-RECEPTOR FUNCTION IN IGA NEPHROPATHY

K NICHOLLS, P KINCAIDSMITH

AMERICAN JOURNAL OF KIDNEY DISEASES | W B SAUNDERS CO | Published : 1984

Abstract

Reticuloendothelial function was assessed in 17 patients with IgA nephropathy, using 99Tc-labeled autologous erythrocytes coated with either C3B or IgG. Results were compared with clearances in 14 normal control subjects and with a group of 14 patients with idiopathic mesangial proliferative glomerulonephritis without IgA deposition. The half-life of IgG-coated red cells in the IgA group was 69.8 +/- 32.5 minutes (control 42.2 +/- 9.0 minutes, P = 0.001). The half-life in the non-IgA mesangial proliferative group, 77.9 +/- 31.3 minutes, was not significantly different from that of the IgA patients. Clearance of C3b-coated cells, expressed as the percentage of cells cleared at 30 minutes, was..

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