BCG plus MMC trial: adding mitomycin C to BCG as adjuvant intravesical therapy for high-risk, non-muscle-invasive bladder cancer: a randomised phase III trial (ANZUP 1301)
Dickon Hayne, Martin Stockler, Steve P McCombie, Venu Chalasani, Anne Long, Andrew Martin, Shomik Sengupta, Ian D Davis
BMC CANCER | BMC | Published : 2015
BACKGROUND: Despite adequate trans-urethral resection of the bladder tumour (TURBT), non-muscle-invasive bladder cancer (NMIBC) is associated with high rates of recurrence and progression. Instillation of Bacillus Calmette-Guérin (BCG) into the urinary bladder after TURBT (adjuvant intravesical administration) reduces the risk of both recurrence and progression, and this is therefore the standard of care for high-risk tumours. However, over 30 % of people still recur or progress despite optimal delivery of BCG. Our meta-analysis suggests that outcomes might be improved further by using an adjuvant intravesical regimen that includes both mitomycin and BCG. These promising findings require cor..View full abstract
This study received funding from Cancer Australia. The authors thank Karen Bracken, Xanthi Coskinas, Peter Stanford, Cynthia Hawks, Angela Ives, Philomena Braganza, Wei Ling Ooi, Julie Sykes, and Greg Bock for their contribution.