Journal article
National institutes of health stroke scale item profiles as predictor of patient outcome: External validation on independent trial data
AH Abdul-Rahim, RL Fulton, H Sucharew, D Kleindorfer, P Khatri, JP Broderick, KR Lees, A Alexandrov, PM Bath, E Bluhmki, N Bornstein, L Claesson, J Curram, SM Davis, G Donnan, HC Diener, M Fisher, M Ginsberg, B Gregson, J Grotta Show all
Stroke | LIPPINCOTT WILLIAMS & WILKINS | Published : 2015
Abstract
BACKGROUND AND PURPOSE - : National Institutes of Health Stroke Scale (NIHSS) item profiles that were recently proposed may prove useful both clinically and for research studies. We aimed to validate the NIHSS item profiles in an acute cohort. METHODS - : We conducted a retrospective analysis on pooled data from randomized clinical trials. We applied the latent class analysis probabilities of profile membership developed from the derivation study to obtain symptom grouping, a-NIHSS item profiles. We implemented an independent latent class analysis to derive secondary symptom grouping, b-NIHSS item profiles. Validation was performed by assessing the associations with outcomes and evaluating b..
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Awarded by National Institute of Neurological Disorders and Stroke
Funding Acknowledgements
Dr Khatri received research support from Genentech and Penumbra (Principal Investigator of A Study of the Efficacy and Safety of Activase [Alteplase] in Patients With Mild Stroke [PRISMS] and Assess the Penumbra System in the Treatment of Acute Stroke [THERAPY] trials) and Data and Safety Monitoring Board member for Biogen. Dr Broderick is awarded research monies to Department of Neurology from Genentech for PRISMS Trial, travel to Australian stroke conference paid for by Boehringer Ingelheim, study medication from Genentech for Interventional Management of Stroke (IMS) III Trial and National Institutes of Health funding for part of his research activities. None of these relate to the content of this article. The other authors report no conflicts.