Specific contributions of CSF-1 and GM-CSF to the dynamics of the mononuclear phagocyte system

C Louis; AD Cook; D Lacey; AJ Fleetwood; R Vlahos; GP Anderson; JA Hamilton

Journal article

Specific contributions of CSF-1 and GM-CSF to the dynamics of the mononuclear phagocyte system

C Louis, AD Cook, D Lacey, AJ Fleetwood, R Vlahos, GP Anderson, JA Hamilton

Journal of Immunology | AMER ASSOC IMMUNOLOGISTS | Published : 2015

DOI: 10.4049/jimmunol.1500369

Abstract

M-CSF (or CSF-1) and GM-CSF can regulate the development and function of the mononuclear phagocyte system (MPS). To address some of the outstanding and sometimes conflicting issues surrounding this biology, we undertook a comparative analysis of the effects of neutralizing mAbs to these CSFs on murine MPS populations in the steady-state and during acute inflammatory reactions. CSF-1 neutralization, but not of GM-CSF, in normal mice rapidly reduced the numbers of more mature Ly6C2 monocytes in blood and bone marrow, without any effect on proliferating precursors, and also the numbers of the resident peritoneal macrophages, observations consistent with CSF-1 signaling being essential only at a..

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University of Melbourne Researchers

Andrew Fleetwood Author

Gary Anderson Author

John Hamilton Author

Grants

Funding Acknowledgements

This work was supported by Project Grants and a Senior Principal Research Fellowship (to J.A.H.) from the National Health and Medical Research Council of Australia, and a University of Melbourne graduate research scholarship (to C.L.).