Specific Contributions of CSF-1 and GM-CSF to the Dynamics of the Mononuclear Phagocyte System
Cynthia Louis, Andrew D Cook, Derek Lacey, Andrew J Fleetwood, Ross Vlahos, Gary P Anderson, John A Hamilton
The Journal of Immunology | AMER ASSOC IMMUNOLOGISTS | Published : 2015
M-CSF (or CSF-1) and GM-CSF can regulate the development and function of the mononuclear phagocyte system (MPS). To address some of the outstanding and sometimes conflicting issues surrounding this biology, we undertook a comparative analysis of the effects of neutralizing mAbs to these CSFs on murine MPS populations in the steady-state and during acute inflammatory reactions. CSF-1 neutralization, but not of GM-CSF, in normal mice rapidly reduced the numbers of more mature Ly6C(-) monocytes in blood and bone marrow, without any effect on proliferating precursors, and also the numbers of the resident peritoneal macrophages, observations consistent with CSF-1 signaling being essential only at..View full abstract
This work was supported by Project Grants and a Senior Principal Research Fellowship (to J.A.H.) from the National Health and Medical Research Council of Australia, and a University of Melbourne graduate research scholarship (to C.L.).