Journal article
Parallel changes in structural and functional measures of optic nerve myelination after optic neuritis
A Van Der Walt, S Kolbe, P Mitchell, Y Wang, H Butzkueven, G Egan, C Yiannikas, S Graham, T Kilpatrick, A Klistorner
Plos One | PUBLIC LIBRARY SCIENCE | Published : 2015
Abstract
Introduction Visual evoked potential (VEP) latency prolongation and optic nerve lesion length after acute optic neuritis (ON) corresponds to the degree of demyelination, while subsequent recovery of latency may represent optic nerve remyelination. We aimed to investigate the relationship between multifocal VEP (mfVEP) latency and optic nerve lesion length after acute ON. Methods Thirty acute ON patients were studied at 1,3,6 and 12 months using mfVEP and at 1 and 12 months with optic nerve MRI. LogMAR and low contrast visual acuity were documented. By one month, the mfVEP amplitude had recovered sufficiently for latency to be measured in 23 (76.7%) patients with seven patients having no reco..
View full abstractGrants
Funding Acknowledgements
This work was supported by the National Health and Medical Research Council (AK, GFE, AV, HB, SCK), Multiple Sclerosis Research Australia grant (AK) and Sydney Foundation for Medical Research (AK). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.