Journal article

Bone morphogenetic protein/retinoic acid inducible neural-specific protein (brinp) expression during Danio rerio development

Aminah Giousoh, Raquel Vaz, Robert J Bryson-Richardson, James C Whisstock, Heather Verkade, Phillip I Bird

GENE EXPRESSION PATTERNS | ELSEVIER SCIENCE BV | Published : 2015

Abstract

Prototype Membrane Attack Complex/Perforin (MACPF) superfamily proteins such as complement and perforin play crucial roles in immune defense where they drive lytic pore formation. However, it is evident that other MACPF family members are important in the central nervous system. For example, three bone morphogenetic protein/retinoic acid inducible neural-specific proteins (Brinp1, Brinp2 and Brinp3) are present in developing and mature mammalian neurons, but their molecular function is unknown. In this study we have identified and cloned full-length orthologues of all three human brinps from Danio rerio (zebrafish). Zebrafish and human brinps show very high sequence conservation, and the chr..

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Grants

Awarded by National Health and Medical Research Council (Australia)


Funding Acknowledgements

This work was supported by the National Health and Medical Research Council (Australia), Program 490900; and the Australian Research Council. We thank FishCore for assistance with fish husbandry.