Journal article

Of monkeys and men: immunomic profiling of sera from humans and non-human primates resistant to schistosomiasis reveals novel potential vaccine candidates

Mark S Pearson, Luke Becker, Patrick Driguez, Neil D Young, Soraya Gaze, Tiago Mendes, Xiao-Hong Li, Denise L Doolan, Nicholas Midzi, Takafira Mduluza, Donald P McManus, R Alan Wilson, Jeffrey M Bethony, Norman Nausch, Francisca Mutapi, Philip L Felgner, Alex Loukas

Frontiers in Immunology | FRONTIERS MEDIA SA | Published : 2015

Abstract

Schistosoma haematobium affects more than 100 million people throughout Africa and is the causative agent of urogenital schistosomiasis. The parasite is strongly associated with urothelial cancer in infected individuals and as such is designated a group I carcinogen by the International Agency for Research on Cancer. Using a protein microarray containing schistosome proteins, we sought to identify antigens that were the targets of protective IgG1 immune responses in S. haematobium-exposed individuals that acquire drug-induced resistance (DIR) to schistosomiasis after praziquantel treatment. Numerous antigens with known vaccine potential were identified, including calpain (Smp80), tetraspanin..

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University of Melbourne Researchers

Grants

Awarded by National Health and Medical Research Council of Australia (NHMRC)


Awarded by Wellcome Trust UK


Awarded by Shanghai Science and Technology Commission


Funding Acknowledgements

We would like to thank the residents and children of Chipinda village as well as the teachers from Chipinda primary and secondary school for their participation and generous and kind support of this study. We are also very grateful for the co-operation of the Ministry of Health and Child Welfare in Zimbabwe. We like to thank the Provincial Medical Director of Mashonaland East, the Environmental Health Workers, and nursing staff at Chitate Clinics and Murehwa Hospital. We are grateful to the members of the National Institutes of Health in Harare and the Biochemistry Department at University of Zimbabwe for technical and logistical support. This research received financial support from the National Health and Medical Research Council of Australia (NHMRC) (Program Grant no: APP1037304), the Wellcome Trust UK (Grant no: WT082028MA), the Cunningham Trust, the Carnegie Trust for the Universities of Scotland, and the Shanghai Science and Technology Commission (Grant no: 15ZR1444300). DM is an NHMRC Senior Principal Research Fellow, AL and DD are NHMRC Principal Research Fellows. NY is an NHMRC Early Career Research Fellow