Journal article

Schizophrenia genetic variants are not associated with intelligence

AF Terwisscha van Scheltinga, SC Bakker, NEM van Haren, EM Derks, JE Buizer-Voskamp, W Cahn, S Ripke, RA Ophoff, RS Kahn

PSYCHOLOGICAL MEDICINE | CAMBRIDGE UNIV PRESS | Published : 2013

Abstract

BACKGROUND: Schizophrenia is associated with lower pre-morbid intelligence (IQ) in addition to (pre-morbid) cognitive decline. Both schizophrenia and IQ are highly heritable traits. Therefore, we hypothesized that genetic variants associated with schizophrenia, including copy number variants (CNVs) and a polygenic schizophrenia (risk) score (PSS), may influence intelligence. METHOD: IQ was estimated with the Wechsler Adult Intelligence Scale (WAIS). CNVs were determined from single nucleotide polymorphism (SNP) data using the QuantiSNP and PennCNV algorithms. For the PSS, odds ratios for genome-wide SNP data were calculated in a sample collected by the Psychiatric Genome-Wide Association Stu..

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University of Melbourne Researchers

Grants

Awarded by Zorg Onderzoek Nederland, Medische Wetenschappen (ZON-MW, the Netherlands Organization for Health Research and Development)


Awarded by Top Institute Pharma (TI-Pharma)


Awarded by National Institute of Mental Health


Awarded by Lundbeck Foundation


Awarded by Medical Research Council


Awarded by NATIONAL INSTITUTE OF MENTAL HEALTH


Funding Acknowledgements

This work was supported by a Veni grant to S. C. B. from Zorg Onderzoek Nederland, Medische Wetenschappen (ZON-MW, the Netherlands Organization for Health Research and Development, project no. 91686137), by Top Institute Pharma (TI-Pharma, project T5-203) and by the National Institute of Mental Health grant RO1 MG 078075 to R.A.O.