Lipotoxic Stress Induces Pancreatic beta-Cell Apoptosis through Modulation of Bcl-2 Proteins by the Ubiquitin-Proteasome System
Sara A Litwak, Jibran A Wali, Evan G Pappas, Hamdi Saadi, William J Stanley, L Chitra Varanasi, Thomas WH Kay, Helen E Thomas, Esteban N Gurzov
Journal of Diabetes Research | HINDAWI LTD | Published : 2015
Awarded by National Health and Medical Research Council of Australia (NHMRC)
The authors thank L Elkerbout, S Fynch, S Thorburn, and C Selck for technical assistance, Dr. S Andrikopoulos (University of Melbourne) for assistance with IV-GTTs, Dr. J Allison (St Vincent's Institute) for RIP-Bcl-2 mice, Professor A Strasser(Walter and Eliza Hall Institute) for PUMA-/- mice, and Dr. T Loudovaris and Ms L Mariana (Australian Islet Transplant Consortium, St Vincent's Institute) for human islets. This work was supported by a National Health and Medical Research Council of Australia (NHMRC) Project Grant (APP1071350) and fellowship (Helen E. Thomas). Esteban N. Gurzov is supported by a Juvenile Diabetes Research Foundation (JDRF) fellowship. The St Vincent's Institute receives support from the Operational Infrastructure Support Scheme of the Government of Victoria.