Verbal memory as a mediator in the relationship between subthreshold depressive symptoms and functional outcome in bipolar disorder
Caterina del Mar Bonnin, Ana Gonzalez-Pinto, Brisa Sole, Maria Reinares, Itxaso Gonzalez-Ortega, Susana Alberich, Jose Manuel Crespo, Manel Salamero, Eduard Vieta, Anabel Martinez-Aran, Carla Torrent
JOURNAL OF AFFECTIVE DISORDERS | ELSEVIER SCIENCE BV | Published : 2014
BACKGROUND: Most studies on the factors involved in the functional outcome of patients with bipolar disorder have identified subsyndromal depressive symptoms and cognitive impairment as key players. However, most studies are cross-sectional and very few have analyzed the interaction between cognition and subclinical depression. The present study aimed to identify the role of cognition, and particularly verbal memory, and subthreshold depressive symptoms in the functional outcome of patients with bipolar I and II disorder at one year follow-up. METHOD: A confirmatory analysis was performed using the path analysis. A total of 111 euthymic patients were included to test the role of verbal memor..View full abstract
Awarded by Spanish Ministry of Economy and Competitiveness
Awarded by Comissionat per a Universitats i Recerca del DIU de la Generalitat de Catalunya
The authors of this report would like to acknowledge the support of the Spanish Ministry of Economy and Competitiveness, (PI030130 and PI08/90825, PI08/90327, PI08/90675, PI08/90224, PI08/90654, PI08/90189, PI08/90916, PI08/90416, PI08/90094) PN 2008-2011, Instituto de Salud Carlos III, Subdireccion General de Evaluacion y Fomento de la Investigacion; Fondo Europeo de Desarrollo Regional. Union Europea, "Una manera de hacer Europa"; CIBERSAM; and the Comissionat per a Universitats i Recerca del DIU de la Generalitat de Catalunya to the Bipolar Disorders Group (2009 SGR 1022). Dr. Anabel Martinez-Aran's project is supported in part by a 2013 NARSAD, Independent Investigator Grant from the Brain & Behavior Research Foundation.