Journal article

Evaluation of p16(INK4a) immunostaining for the detection of high-grade changes in cervical cytology

Sepehr N Tabrizi, Sarah E Tan, Christina von Knebel Doeberitz, Jeffery Tan, Michael A Quinn, Suzanne M Garland



Since its introduction in Australia in 2007, the human papillomavirus (HPV) vaccine has led to a markedly lower prevalence of vaccine targeted HPV genotype infections as well as HPV disease including genital warts and histologically confirmed high-grade (HG) cervical abnormalities. To increase the ability to identify abnormal cells in lower prevalence, adjunct markers can be incorporated to improve the sensitivity and specificity of cytology test. One such marker is p16(p16), which is detectable in cells expressing the E7 oncogene encoded by high-risk HPVs (HR-HPV). In this study, the sensitivity and specificity of p16 immunostaining in detection of underlying HG lesions was evaluated in a c..

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