Journal article

Myb via TGF beta is required for collagen type 1 production and skin integrity

Shienny Sampurno, Ryan Cross, Helen Pearson, Pritinder Kaur, Jordane Malaterre, Robert G Ramsay

GROWTH FACTORS | INFORMA HEALTHCARE | Published : 2015

Abstract

Skin integrity requires an ongoing replacement and repair orchestrated by several cell types. We previously investigated the architecture of the skin of avian myeloblastosis viral oncogene homolog (Myb) knock-out (KO) embryos and wound repair in Myb(+/)(-) mice revealing a need for Myb in the skin, attributed to fibroblast-dependent production of collagen type 1. Here, using targeted Myb deletion in keratin-14 (K14) positive cells we reveal further Myb-specific defects in epidermal cell proliferation, thickness and ultrastructural morphology. This was associated with a severe deficit in collagen type 1 production, reminiscent of that observed in patients with ichthyosis vulgaris and Ehlers-D..

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