Astrocyte and Microglial Control of Glutamatergic Signalling: A Primer on Understanding the Disruptive Role of Chronic Stress
J Mayhew, PM Beart, FR Walker
Journal of Neuroendocrinology | WILEY | Published : 2015
It is now well established that chronic stress can induce significant structural remodelling of astrocytes and microglia. Until recently, however, the full significance of these morphological disturbances has remained unclear. Clues to the significance of astroglial re-organisation following stress are beginning to emerge from a compelling literature describing how astrocytes contribute to glutamatergic neurotransmission. The present review briefly summarises these two fields of research, identifies points of overlap and, in doing so, pin-points future research directions for stress neurobiology. Ultimately, understanding how chronic stress can disrupt the interactions of astrocytes and micr..View full abstract
Related Projects (1)
Awarded by NHMRC
FRW acknowledges support from the NHMRC. PMB was supported by NHMRC Research Fellowships APP1019833. The Florey Institute of Neuroscience and Mental Health receives infrastructure support from the Victorian State Government (Australia).