Conference Proceedings
SYNERGISM BETWEEN GM-CSF AND IL-17 CAUSES ENHANCED JOINT PATHOLOGY VIA THE PRODUCTION OF IL-6 AND IL-23
AE van Nieuwenhuijze, DM Roeleveld, B Walgreen, MM Helsen, L van den Bersselaar, IP Wicks, WB van den Berg, FA van de Loo, MI Koenders
ANNALS OF THE RHEUMATIC DISEASES | BMJ PUBLISHING GROUP | Published : 2014
Abstract
Background T helper-17 (Th17) cells are important mediators of inflammatory diseases, and are the main pathogenic cell type in many animal models of autoimmunity. Recent studies highlight a surprising role for T-cell derived granulocyte-macrophage colony stimulating factor (GM-CSF) in the pathogenicity of Th17 cells. Objectives We examined the mechanism by which interleukin 17 (IL-17) and GM-CSF contribute to cartilage- and bone damage of synovial joints during experimental arthritis, and investigated their potential additive and synergistic effects to provide a rationale for combination therapy in auto-inflammatory conditions. Methods Collagen-induced arthritis (CIA) was elicited in DBA/1J ..
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