Journal article
Multiple novel prostate cancer susceptibility signals identified by fine-mapping of known risk loci among Europeans
AA Al Olama, T Dadaev, DJ Hazelett, Q Li, D Leongamornlert, EJ Saunders, S Stephens, C Cieza-Borrella, I Whitmore, SB Garcia, GG Giles, MC Southey, L Fitzgerald, H Gronberg, F Wiklund, M Aly, BE Henderson, F Schumacher, CA Haiman, J Schleutker Show all
Human Molecular Genetics | Published : 2015
DOI: 10.1093/hmg/ddv203
Abstract
Genome-wide association studies (GWAS) have identified numerouscommon prostate cancer (PrCa) susceptibility loci. We have fine-mapped 64 GWAS regions known at the conclusion of the iCOGS study using large-scale genotyping and imputation in 25 723 PrCa cases and 26 274 controls of European ancestry. We detected evidence for multiple independent signals at 16 regions, 12 of which contained additional newly identified significant associations. A single signal comprising a spectrum of correlated variationwas observed at 39 regions; 35 of which are nowdescribed by a novel more significantly associated lead SNP, while the originally reported variant remained as the lead SNP only in 4 regions. We a..
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Awarded by National Institutes of Health
Funding Acknowledgements
This work was supported by European Commission's Seventh Framework Programme grant agreement No. 223175 (HEALTH-F2-2009-223175), Cancer Research UK Grants C5047/A7357, C1287/A10118, C5047/A3354, C5047/A10692, C16913/A6135 and The National Institute of Health (NIH) Cancer Post-Cancer GWAS initiative grant: No. 1 U19 CA 148537-01 (the GAME-ON initiative). Funding to pay the Open Access publication charges for this article was provided by the Institute of Cancer Research.