Journal article

Ultrasonographic assessment of splenic volume at presentation and after anti-malarial therapy in children with malarial anaemia

Moses Laman, Susan Aipit, Cathy Bona, Peter M Siba, Leanne J Robinson, Laurens Manning, Timothy ME Davis

MALARIA JOURNAL | BMC | Published : 2015


BACKGROUND: Splenic enlargement is a component of the host response to malaria and may also influence the genesis and progression of malarial anaemia. Few cross-sectional and no longitudinal studies have assessed the relationship between splenic volume measured ultrasonographically and haemoglobin concentrations in children with malaria. METHODS: Fifteen Papua New Guinean children with severe malarial anaemia (SMA; haemoglobin<50 g/L) and ten with moderate malarial anaemia (MMA; 51-99 g/L) were recruited. The SMA patients were given intramuscular artemether followed by oral artemisinin combination therapy (ACT), and were transfused one unit of packed cells 0.3-4.0 days post-admission. The MM..

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University of Melbourne Researchers


Awarded by National Health and Medical Research Council (NHMRC)

Awarded by NHMRC

Funding Acknowledgements

The authors gratefully acknowledge support from staff from the Modilon Hospital Paediatrics Ward, the Mugil Health Centre and the Vector Borne Diseases Unit of the Papua New Guinea Institute of Medical Research. We also thank Steven Fraser and Michelle Bavcevic for assistance with preparation of Figures and Wendy Davis for statistical advice. The children with SMA were recruited as part of a severe childhood illness study funded by a National Health and Medical Research Council (NHMRC) grant (#513782) while those with MMA were recruited as part of screening for an anti-malarial intervention trial also funded by NHMRC(#634343). ML was supported by a Fogarty Foundation scholarship and an Australian PhD Scholarship Award, LM by a Basser Award from the Royal Australasian College of Physicians and a postgraduate NHMRC scholarship, and TMED by an NHMRC Practitioner Fellowship.