Journal article
Glycoprotein A33 deficiency: A new mouse model of impaired intestinal epithelial barrier function and inflammatory disease
BB Williams, NC Tebbutt, M Buchert, TL Putoczki, K Doggett, S Bao, CN Johnstone, F Masson, F Hollande, AW Burgess, AM Scott, M Ernst, JK Heath
Dmm Disease Models and Mechanisms | Published : 2015
DOI: 10.1242/dmm.019935
Open access
Abstract
The cells of the intestinal epithelium provide a selectively permeable barrier between the external environment and internal tissues. The integrity of this barrier is maintained by tight junctions, specialised cell-cell contacts that permit the absorption of water and nutrients while excluding microbes, toxins and dietary antigens. Impairment of intestinal barrier function contributes to multiple gastrointestinal disorders, including food hypersensitivity, inflammatory bowel disease (IBD) and colitis-associated cancer (CAC). Glycoprotein A33 (GPA33) is an intestinal epithelium-specific cell surface marker and member of the CTX group of transmembrane proteins. Roles in cell-cell adhesion have..
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Funding Acknowledgements
This research was supported by Program grant 487922 (A.W.B., A.M.S., M.E. and J.K.H.), Senior Research Fellowships 6031222 and 1022870 (M.E. and J.K.H., respectively) and a Medical Postgraduate Award (N.C.T.) from the National Health and Medical Research Council (NHMRC) of Australia. This work was also funded by Ludwig Cancer Research and operational infrastructure grants from the Australian Federal Government (IRISS) and the Victorian State Government (OIS).