Journal article

Sudden Death in Childhood Cardiomyopathy Results From a Long-Term National Population-Based Study

Tara Bharucha, Katherine J Lee, Piers EF Daubeney, Alan W Nugent, Christian Turner, Gary F Sholler, Terry Robertson, Robert Justo, Jim Ramsay, John B Carlin, Steven D Colan, Ingrid King, Robert G Weintraub, Andrew M Davis



BACKGROUND: Children with cardiomyopathy (CM) are at risk of sudden cardiac death (SCD), but the incidence and risk factors for this outcome are not clear. OBJECTIVES: This study sought to determine the incidence and risk factors for SCD in children with varying CM phenotypes from a long-term population-based study of childhood CM. METHODS: The NACCS (National Australian Childhood Cardiomyopathy Study) is an ongoing longitudinal cohort study including all children in Australia with primary CM who were diagnosed between January 1, 1987, and December 31, 1996, and were <10 years of age. The cumulative incidence and risk factors for SCD within individual CM phenotypes were explored using surviv..

View full abstract


Awarded by Royal Children's Hospital Research Foundation

Awarded by National Heart Foundation of Australia

Funding Acknowledgements

This study was supported by the Royal Children's Hospital Research Foundation (grant 98001), the National Heart Foundation of Australia (grants G 98M 0159, G 04M 1586, G 05M 2151, and G 07M 3180), the Australia and New Zealand Children's Heart Research Centre (NACCS grant), and Heartkids Australia (NACCS grant). Dr. Daubeney is supported by the Biomedical Research Unit at the Royal Brompton Hospital. The Department of Cardiology, Royal Children's Hospital, receives fellowship support from Medtronic and St. Jude Medical. Dr. Weintraub has served on an advisory board for Actelion Pharmaceuticals. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.