Journal article

Malaria preventive therapy in pregnancy and its potential impact on immunity to malaria in an area of declining transmission

Andrew Teo, Wina Hasang, Louise M Randall, Holger W Unger, Peter M Siba, Ivo Mueller, Graham V Brown, Stephen J Rogerson



BACKGROUND: Regular anti-malarial therapy in pregnancy, a pillar of malaria control, may affect malaria immunity, with therapeutic implications in regions of reducing transmission. METHODS: Plasma antibodies to leading vaccine candidate merozoite antigens and opsonizing antibodies to endothelial-binding and placental-binding infected erythrocytes were quantified in pregnant Melanesian women receiving sulfadoxine-pyrimethamine (SP) with chloroquine taken once, or three courses of SP with azithromycin. RESULTS: Malaria prevalence was low. Between enrolment and delivery, antibodies to recombinant antigens declined in both groups (p<0.0001). In contrast, median levels of opsonizing antibodies di..

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Awarded by National Health and Medical Research council of Australia

Funding Acknowledgements

This study was supported by National Health and Medical Research council of Australia awarded to SJR and GVB, Grant number: 10244441. Sample collection was supported in part by Malaria in Pregnancy Consortium, which receives funding from the Bill and Melinda Gates Foundation. The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript.