The peroxisome proliferator activated receptor gamma agonist pioglitazone increases functional expression of the glutamate transporter excitatory amino acid transporter 2 (EAAT2) in human glioblastoma cells
Jared Ching, Stephanie Amiridis, Stanley S Stylli, Andrew R Bjorksten, Nicole Kountouri, Thomas Zheng, Lucy Paradiso, Rodney B Luwor, Andrew P Morokoff, Terence J O'Brien, Andrew H Kaye
ONCOTARGET | IMPACT JOURNALS LLC | Published : 2015
Glioma cells release glutamate through expression of system xc-, which exchanges intracellular glutamate for extracellular cysteine. Lack of the excitatory amino acid transporter 2 (EAAT2) expression maintains high extracellular glutamate levels in the glioma microenvironment, causing excitotoxicity to surrounding parenchyma. Not only does this contribute to the survival and proliferation of glioma cells, but is involved in the pathophysiology of tumour-associated epilepsy (TAE). We investigated the role of the peroxisome proliferator activated receptor gamma (PPARγ) agonist pioglitazone in modulating EAAT2 expression in glioma cells. We found that EAAT2 expression was increased in a dose de..View full abstract
This study was supported by The Royal Melbourne Hospital Neuroscience Foundation and National Health Institutes.