Journal article

Connectivity-based fixel enhancement: Whole-brain statistical analysis of diffusion MRI measures in the presence of crossing fibres

David A Raffelt, Robert E Smith, Gerard R Ridgway, J-Donald Tournier, David N Vaughan, Stephen Rose, Robert Henderson, Alan Connelly



In brain regions containing crossing fibre bundles, voxel-average diffusion MRI measures such as fractional anisotropy (FA) are difficult to interpret, and lack within-voxel single fibre population specificity. Recent work has focused on the development of more interpretable quantitative measures that can be associated with a specific fibre population within a voxel containing crossing fibres (herein we use fixel to refer to a specific fibre population within a single voxel). Unfortunately, traditional 3D methods for smoothing and cluster-based statistical inference cannot be used for voxel-based analysis of these measures, since the local neighbourhood for smoothing and cluster formation ca..

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Awarded by UK Medical Research Council

Awarded by Wellcome Trust

Awarded by MRC

Awarded by Medical Research Council

Funding Acknowledgements

We are grateful to the National Health and Medical Research Council (NHMRC) of Australia and the Victorian Government's Operational Infrastructure Support Program for their support. GRR is supported by the UK Medical Research Council (grant number MR/J014257/1). The Wellcome Trust Centre for Neuroimaging is supported by core funding from the Wellcome Trust (grant number 091593/Z/10/Z).