Systematic Screening Identifies Dual PI3K and mTOR Inhibition as a Conserved Therapeutic Vulnerability in Osteosarcoma
Ankita Gupte, Emma K Baker, Soo-San Wan, Elizabeth Stewart, Amos Loh, Anang A Shelat, Cathryn M Gould, Alistair M Chalk, Scott Taylor, Kurt Lackovic, Asa Karlstroem, Anthony J Mutsaers, Jayesh Desai, Piyush B Madhamshettiwar, Andrew CW Zannettino, Chris Burns, David CS Huang, Michael A Dyer, Kaylene J Simpson, Carl R Walkley
Clinical Cancer Research | AMER ASSOC CANCER RESEARCH | Published : 2015
Awarded by AACR-Aflac Inc, Career Development Award for Pediatric Cancer Research
Awarded by Cancer Council of Victoria
Awarded by NHMRC
Awarded by LLS Specialized Center of Research
This work was supported by grants from the AACR-Aflac Inc, Career Development Award for Pediatric Cancer Research (to C.R. Walkley; 12-20-10-WALK); Colin North (to C.R. Walkley); Zig Inge Foundation (to C.R. Walkley); 5-point foundation (to E.K. Baker); Cancer Council of Victoria (to C.R. Walkley and E.K. Baker; grant-in-aid APP1047593); NHMRC Career Development Award (to C.R. Walkley; APP559016); NHMRC Research Fellowship (to D.C.S. Huang; APP1043149); Cure Cancer Australia Foundation Fellowship (to E.K. Baker); NHMRC program grant (to D.C.S. Huang; APP1016701); LLS Specialized Center of Research (C. Burns and D.C.S. Huang; 7001-13); NHMRC IRIIS grant (to St. Vincent's Institute [SVI] and Walter and Eliza Hall Institute [WEHI]); in part by the Victorian State Government Operational Infrastructure Support Program (to SVI and WEHI); The Victorian Centre for Functional Genomics is funded by the Australian Cancer Research Foundation (ACRF), the Victorian Department of Industry, Innovation and Regional Development (DIIRD), the Australian Phenomics Network (APN), and supported by funding from the Australian Government's Education Investment Fund through the Super Science Initiative, the Australasian Genomics Technologies Association (AMATA), the Brockhoff Foundation and the Peter MacCallum Cancer Centre Foundation; M.A. Dyer is an Investigator of the Howard Hughes Medical Institute; C.R. Walkley is the Philip Desbrow Senior Research Fellow of the Leukaemia Foundation.