Journal article

Monosomal karyotype predicts inferior survival independently of a complex karyotype in patients with myelodysplastic syndromes

Zoe K McQuilten, Vijaya Sundararajan, Nick Andrianopoulos, David J Curtis, Erica M Wood, Lynda J Campbell, Meaghan Wall

CANCER | WILEY | Published : 2015


BACKGROUND: Conflicting data exist about the impact of a monosomal karyotype (MK) on overall survival (OS) for patients with myelodysplastic syndromes (MDSs) and particularly for those with a complex karyotype (CK). This study was aimed at determining whether an MK is associated with OS independently of the number of cytogenetic abnormalities (CAs) in a population-based MDS cohort. METHODS: Cancer registry data on incident MDS cases were linked with cytogenetic data and hospital administrative data from 2000 to 2010 for the Australian state of Victoria. RESULTS: Between 2000 and 2010, 1404 incident MDS cases with cytogenetic results were identified. A CK, defined as 3 or more abnormalities, ..

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Awarded by Australian National Health and Medical Research Council

Funding Acknowledgements

This work was supported by grants to Meaghan Wall from the Victorian Cancer Agency and the Leukaemia Foundation of Australia. Zoe K. McQuilten was supported by the Australian National Health and Medical Research Council through a postgraduate scholarship (APP1017942).