Journal article

Incomplete penetrance: The role of stochasticity in developmental cell colonization

Benjamin J Binder, Kerry A Landman, Donald E Newgreen, Joshua V Ross

JOURNAL OF THEORETICAL BIOLOGY | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD | Published : 2015

Abstract

Cell colonization during embryonic development involves cells migrating and proliferating over growing tissues. Unsuccessful colonization, resulting from genetic causes, can result in various birth defects. However not all individuals with the same mutation show the disease. This is termed incomplete penetrance, and it even extends to discordancy in monozygotic (identical) twins. A one-dimensional agent-based model of cell migration and proliferation within a growing tissue is presented, where the position of every cell is recorded at any time. We develop a new model that approximates this agent-based process - rather than requiring the precise configuration of cells within the tissue, the n..

View full abstract

Grants

Awarded by Australian Research Council Future Fellowship (ARC)


Funding Acknowledgements

The contributions of Binder, Landman and Newgreen were supported by the National Health and Medical Research Council. The contribution of Ross was supported by an Australian Research Council Future Fellowship (ARC FT130100254). MCRI facilities are supported by the Victorian Governments Operational Infrastructure Support Program.