Journal article

Genome-Wide Transcriptome Directed Pathway Analysis of Maternal Pre-Eclampsia Susceptibility Genes

Hannah EJ Yong, Phillip E Melton, Matthew P Johnson, Katy A Freed, Bill Kalionis, Padma Murthi, Shaun P Brennecke, Rosemary J Keogh, Eric K Moses

PLOS ONE | PUBLIC LIBRARY SCIENCE | Published : 2015

Abstract

BACKGROUND: Preeclampsia (PE) is a serious hypertensive pregnancy disorder with a significant genetic component. Numerous genetic studies, including our own, have yielded many susceptibility genes from distinct functional groups. Additionally, transcriptome profiling of tissues at the maternal-fetal interface has likewise yielded many differentially expressed genes. Often there is little overlap between these two approaches, although genes identified in both approaches are significantly associated with PE. We have thus taken a novel integrative bioinformatics approach of analysing pathways common to the susceptibility genes and the PE transcriptome. METHODS: Using Illumina Human Ht12v4 and W..

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Grants

Awarded by National Institutes of Health


Awarded by National Health and Medical Research Council


Awarded by National Center for Research Resources, National Institutes of Health


Awarded by EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT


Awarded by NATIONAL CENTER FOR RESEARCH RESOURCES


Funding Acknowledgements

This work was supported by the National Institutes of Health [HD049847 to E.K.M. and S.P.B.], the National Health and Medical Research Council [APP1053152 to E.K.M. and S.P.B.], and the Faye L. and William L. Cowden Charitable Foundation (to M. P.J.). H.E.J.Y. was supported by the Australian Society for Medical Research 2013 Domestic Research Travel Award, the University of Melbourne's Melbourne International Fee Remission Scholarship, and the Felix Meyer Scholarship in Obstetrics and Gynaecology. Transcriptional profiling was conducted in facilities constructed with support from Research Facilities Improvement Program grant RR017515 from the National Center for Research Resources, National Institutes of Health. National Institutes of Health: grants.nih.gov; National Health and Medical Research Council: http://www.nhmrc.gov.au/; Faye L. and William L. Cowden Charitable Foundation: http://www.broadwaybank.com/wealthmanagement/FoundationFayeLWilliamLCowden.html; Australian Society for Medical Research: www.asmr.org.au; The University of Melbourne: www.unimelb.edu.au.