Journal article

Is S-Adenosyl Methionine (SAMe) for Depression Only Effective in Males? A Re-Analysis of Data from a Randomized Clinical Trial

J Sarris, LH Price, LL Carpenter, AR Tyrka, CH Ng, GI Papakostas, A Jaeger, M Fava, D Mischoulon

PHARMACOPSYCHIATRY | GEORG THIEME VERLAG KG | Published : 2015

Abstract

OBJECTIVE: The aim of this study was to examine whether gender differences may have affected treatment response to S-adenosyl methionine (SAMe) in a recent failed randomized clinical trial (RCT) for adults with major depressive disorder. METHODS: Data from a 2-site, 12-week, double-blind RCT (n=189) assessing the efficacy of SAMe vs. placebo and a comparator selective serotonin reuptake inhibitor (escitalopram) were subjected to post-hoc analyses to evaluate effects of patient gender on treatment response. RESULTS: When assessing the efficacy outcomes within each gender separately, SAMe was superior to placebo among males (n=51), but not among females (n=62). Males showed a significant reduc..

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Grants

Awarded by National Center for Complementary Added Alternative Medicine (NCCAM), R01 grant


Awarded by NATIONAL CENTER FOR COMPLEMENTARY &ALTERNATIVE MEDICINE


Funding Acknowledgements

The study was supported by the NIH and the National Center for Complementary Added Alternative Medicine (NCCAM), R01 grant R01AT001638. Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the National Center for Complementary and Alternative Medicine, National Institutes of Health. SAMe tosylate and matching placebo were supplied by Pharmavite LLC, California. Dr. Jerome Sarris is supported by a CR Roper Fellowship.