The association between major depressive disorder, use of antidepressants and bone mineral density (BMD) in men
PH Rauma, JA Pasco, M Berk, AL Stuart, H Koivumaa-Honkanen, RJ Honkanen, JM Hodge, LJ Williams
Journal of musculoskeletal & neuronal interactions | JMNI | Published : 2015
OBJECTIVE: Both depression and use of antidepressants have been negatively associated with bone mineral density (BMD) but mainly in studies among postmenopausal women. Therefore, the aim of this study was to investigate these relationships in men. METHODS: Between 2006 and 2011, 928 men (aged 24-98 years) from the Geelong Osteoporosis Study completed a comprehensive questionnaire, clinical measurements and had BMD assessments at the forearm, spine, total hip and total body. Major depressive disorder (MDD) was identified using a structured clinical interview (SCID-I/NP). The cross-sectional associations between BMD and both MDD and antidepressant use were analyzed using multivariable linear r..View full abstract
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Awarded by National Health and Medical Research Council (NHMRC)
Awarded by NHMRC
The GOS is supported by grants from the National Health and Medical Research Council (NHMRC 299831, 628582 and 1009367). PHR received a travel grant and research support from the Saastamoinen Foundation, research support from National Doctoral Programme of Musculoskeletal Disorders and Biomaterials, Finnish Concordia Fund, North Savo Regional Fund of Finnish Cultural Foundation and an EVO grant from Lapland Hospital District. MB is supported by a NHMRC Senior Principal Research Fellowship (1059660). HK-H and RJH received an EVO grant from Lapland Hospital District. JMH is supported by a NHMRC. LJW is supported by a NHMRC Career Development Fellowship (1064272).