Journal article

Synthesis of 2-(Benzylthio)-4-(trifluoromethyl)thiazole-5-carboxylates Using S-Benzylisothiouronium Halides as Thiol Equivalents

Shane M Hickey, Jonathan M White, Frederick M Pfeffer, Trent D Ashton

Synlett | GEORG THIEME VERLAG KG | Published : 2015


S-Benzylisothiouronium halides are used as shelf-stable, odorless thiol equivalents. The method developed is used to access 2-(benzylthio)-4-(trifluoromethyl)thiazole carboxyl building blocks. Using the latent trifluoromethyl substituent the reactions could be monitored using 19F NMR spectroscopy.

University of Melbourne Researchers


Awarded by ARC

Funding Acknowledgements

S.M.H., F.M.P., and T.D.A. thank the ARC (LP100100087) and the Strategic Research Centre for Chemistry and Biotechnology (Deakin University) for financial support and a top-up scholarship for S.M.H. The authors would also like to thank the ARC for funding Deakin University's Nuclear Magnetic Resonance Facility through LIEF grant LE110100141, as well as for additional equipment support related to this project (LE120100213).