Journal article
The relationships between IFNL4 genotype, intrahepatic interferon-stimulated gene expression and interferon treatment response differs in HCV-1 compared with HCV-3
JA Holmes, M Congiu, S Bonanzinga, MK Sandhu, YH Kia, SJ Bell, T Nguyen, DM Iser, K Visvanathan, W Sievert, DS Bowden, PV Desmond, AJ Thompson
Alimentary Pharmacology and Therapeutics | Published : 2015
DOI: 10.1111/apt.13263
Abstract
Background The biological mechanism underlying the association between IFNL4/IFNL3 polymorphism and peginterferon/ribavirin (PR) response in HCV-1 is thought to involve differential intrahepatic interferon-stimulated gene expression. HCV-3 is more sensitive to PR, but there are no studies of the association between IFNL4 polymorphism, PR treatment response and liver interferon-stimulated gene expression in HCV-3. Aim We evaluated the association between IFNL4/IFNL3 genotypes, PR treatment outcomes and intrahepatic interferon-stimulated gene expression, according to HCV genotype. Methods HCV-1 and HCV-3 patients who received PR therapy were identified. IFNL3 (rs12979860) and IFNL4 genotype (r..
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Funding Acknowledgements
Funding was provided by the St Vincent's Hospital Research Endowment Fund for this project.