Journal article

Technical quality assurance during the TROG 03.04 RADAR prostate radiotherapy trial: Are the results reflected in observed toxicity rates?

Martin A Ebert, Max Bulsara, Annette Haworth, Rachel Kearvell, Sharon Richardson, Angel Kennedy, Nigel A Spry, Sean A Bydder, David J Joseph, James W Denham



INTRODUCTION: Multicentre radiotherapy clinical trials can incorporate quality assurance (QA) procedures for ensuring consistent application of the trial protocol in the planning, delivery and reporting of participant treatments. Subsequently detected variations from trial protocol have previously been shown to reduce treatment efficacy, although little has been shown for toxicity rates. The purpose of this study was to investigate the association of QA measures and protocol variations on toxicity incidence in the context of a prostate radiotherapy trial. METHODS: Using QA records from the TROG 03.04 RADAR trial, the impact of variations on gastrointestinal (GI) and genito-urinary (GU) toxic..

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University of Melbourne Researchers


Awarded by Diagnostics and Technology Branch of the Australian Government Department of Health and Ageing

Awarded by National Health and Medical Research Council

Funding Acknowledgements

We acknowledge funding from Cancer Australia and the Diagnostics and Technology Branch of the Australian Government Department of Health and Ageing (grant 501106), the National Health and Medical Research Council (grants 300705, 455521, 1006447), the Hunter Medical Research Institute, the Health Research Council (New Zealand), the University of Newcastle the Calvary Mater Newcastle, the Abbott Laboratories and the Novartis Pharmaceuticals. We gratefully acknowledge the support of the Sir Charles Gairdner Hospital, the 'Elvis' study team, the contour audit team, participating RADAR centres, Chantelle Wilcox, the Trans-Tasman Radiation Oncology Group, Jean Ball, Cate Sproston, Sean Hall, Celia Gordon, Scott Chandler, Scott Williams, Mahesh Kumar, Rhonda Coleman, David Lamb, Judy Murray, Ben Hooton and Elizabeth van der Wath.