Journal article

Broadening the definition of autoinflammation

Seth L Masters

SEMINARS IN IMMUNOPATHOLOGY | SPRINGER HEIDELBERG | Published : 2015

Abstract

Initially, the concept of autoinflammation posited that there be no involvement of autoreactive B or T cells, and no evidence of infection. These criteria served well to help establish the concept, and distinguish autoinflammatory diseases from autoimmune or infectious conditions. However, the characterisation of additional monogenic autoinflammatory diseases has established that a primary trigger of the innate immune system may also be accompanied by infection or manifestations of autoimmunity, which may even contribute to pathogenesis. This issue of Seminars in Immunopathology draws out these themes and also shows how autoinflammation can help to maintain homeostasis, which is its primary ..

View full abstract

University of Melbourne Researchers