Journal article

The LIM-domain only protein 4 contributes to lung epithelial cell proliferation but is not essential for tumor progression

Aliaksei Z Holik, Caitlin E Filby, Julie Pasquet, Kati Viitaniemi, John Ciciulla, Kate D Sutherland, Marie-Liesse Asselin-Labat

Respiratory Research | BIOMED CENTRAL LTD | Published : 2015

Abstract

BACKGROUND: The lung is constantly exposed to environmental challenges and must rapidly respond to external insults. Mechanisms involved in the repair of the damaged lung involve expansion of different epithelial cells to repopulate the injured cellular compartment. However, factors regulating cell proliferation following lung injury remain poorly understood. Here we studied the role of the transcriptional regulator Lmo4 during lung development, in the regulation of adult lung epithelial cell proliferation following lung damage and in the context of oncogenic transformation. METHODS: To study the role of Lmo4 in embryonic lung development, lung repair and tumorigenesis, we used conditional k..

View full abstract

Grants

Awarded by Australian Government NHMRC IRIISS, NHMRC Project Grant


Awarded by Worldwide Cancer Research grant


Awarded by Worldwide Cancer Research


Funding Acknowledgements

The authors thank A/Prof Bertoncello for critical reading of the manuscript. We thank A/Prof G. Belz for providing PR8 virus and expert advice, Liana Mackiewicz for technical expertise, Lachlan Whitehead for image quantification script. We thank the Victorian Cancer Biobank for Tissue Microarray. MLAL is supported by an Australian Research Council Queen Elizabeth II Fellowships. This work was made possible through Victorian State Government Operational Infrastructure Support and Australian Government NHMRC IRIISS, NHMRC Project Grant APP1045810 and Worldwide Cancer Research grant 14-0433.